Microbicide Trials Network

MTN-002

The first study of a candidate topical microbicide ever to be conducted in pregnant women, MTN-002 sought to understand whether microbicides being developed for women to protect themselves against HIV are safe if used during pregnancy. The Phase I study involved giving a single dose of tenofovir gel to 16 healthy, HIV-uninfected women hours before they gave birth by scheduled Cesarean section. Results, reported in May 2010, found only small amounts of drug were absorbed into the mother’s bloodstream, amniotic fluid and umbilical cord (fetal) blood; and no serious side effects in either the mothers or their newborns.

 

See

Researchers report results of first microbicide trial in pregnant women

Study indicates small amount of drug passes to fetus

23-May-2010

  

Trial is first to see if HIV prevention gels are safe for pregnant women & their babies

12-June-2008

  

MTN-002 Backgrounder

23-May-2010

  

MTN-002 Q&A

23-May-2010

 

See Also

MTN-002 Protocol

  

MTN-016