MTN-003
- Protocol Title
- VOICE Study – Vaginal and Oral Interventions to Control the Epidemic
- DAIDS Protocol ID
- 10622
- Status
- In development
- The VOICE Study – Vaginal and Oral Interventions to Control the Epidemic –is the first study to compare the safety and efficacy of oral versus topical pre-exposure prophylaxis (PrEP) for prevention of sexual transmission of HIV. VOICE is designed as a five-arm, double-blinded study in which women are first randomized to receive either gel or oral PrEP, and then within each group, randomly assigned to either tenofovir topical gel or placebo gel; or to oral tenofovir, oral Truvada or oral placebo. The study will enroll 4,200 women at 10 sites in South Africa, Malawi, Uganda, Zambia and Zimbabwe.