Microbicide Trials Network

Laboratory Center (LC)

The Laboratory Center (LC) is responsible for overseeing the collection, testing and reporting of results from biologic samples; assisting in the development and quality assurance (QA) of local laboratory capacity at study sites; and identifying and implementing state-of-the-art assays and technologies to advance the scientific agenda of the MTN.

 

The LC is based at the University of Pittsburgh and Magee-Womens Research Institute (MWRI), and is led by LC Principal Investigator (PI) Charlene Dezzutti, Ph.D.

 

The LC provides support for laboratory-related issues and basic and translational science to MTN protocols and study teams through three scientific cores: the Protocol Support Core, based at MRWI; the Virology Core, which is located at the University of Pittsburgh School of Medicine; and the Pharmacology Core with labs at Johns Hopkins University (JHU) and the University of Colorado.

 

Dr. Dezzutti leads the Protocol Support Core, serving as its PI. The Protocol Support Core consists of a formulation testing program led by Lisa Rohan, Ph.D., a mucosal immunology lab that Ian McGowan, M.D., Ph.D., directs, and a microbiology lab led by Sharon Hillier, Ph.D.

 

The Virology Core is under the direction of John Mellors, M.D., who is the PI, with Urvi Parikh, Ph.D., serving as associate director; while the PI of the Pharmacology Core is Craig Hendrix, M.D., and Peter Anderson, Pharm.D., its co-PI.

 

MTN LC activities and responsibilities include:

·       Pre-clinical evaluation of microbicide formulations for tissue safety, anti-HIV efficacy, and compliance with study-specific tests

·       Protocol development and review

·       Development of Study Specific Procedure manuals

·       Pre-study implementation training

·       Technical assistance to the site laboratories

·       Quality Assurance and Quality Control oversight

·       Site laboratory visits

·       Cross Network collaboration

·       Specimen storage and testing

·       Publication of findings related to assay development, microbicide evaluation, and protocol-related studies.

 

View the Laboratory Center Organizational Chart below.

 

Contact the Laboratory Center Principal Investigator Charlene Dezzutti, Ph.D.

 

Email Groups

LC Site Support Email Group

LC Virology Lab Support Email Group

LC Mucosal Immunology Lab Support Email Group

 

Laboratory Center Site Support Individual Contacts

Edward (Ted) Livant

Laboratory Center International Site Support

 

Wayne Hall

Laboratory Center Site Support

 

Ratiya Pamela Kunjara Na Ayudhya

Laboratory Center Manager/Supervisor

 

Lorna Rabe

Laboratory Center Manager/Supervisor

 

May Beamer

Laboratory Center Manager/Supervisor

 

More information about Laboratory Center can be found in the MTN Manual of Operational Procedures, Section 15, Laboratory Issues.

 

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Laboratory Center Organizational Chart2016-Nov-07104.5 KB