Microbicide Trials Network

Image Gallery

The following images are available for download. Unless otherwise noted, please credit Microbicide Trials Network, University of Pittsburgh and Magee-Womens Research Institute. If you have questions about these images or would like additional caption information, please contact Lisa Rossi at rossil@upmc.edu or Clare Collins at collcx@upmc.edu.

 

Microbicides

 

Different

formulations 1

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Different

formulations 2

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microbicide film

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study gel and

applicator

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tenofovir tablet with gel image

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Microbicides can be formulated in different ways.

 

Research

 

 

Research 1

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Research 2

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Using a unique tissue explant model that very closely mimics how HIV infects cells of the cervix or rectum, MTN researchers are able to test different products for their safety and effectiveness.

 

 

Research 3

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Research 4

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Research 5

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MTN researchers perform studies that assess the stability of drug compounds in different formulations of microbicides.

 

Research 6

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MTN researchers look closely for any effects that microbicides may have on the normal population of vaginal microflora, studies that are important for assessing the safety of different products.

 

People

 

Jared Baeten

MTN Co-Principal Investigator

Leadership and Operations Center

University of Washington Support Core

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Credit: University of Washington

 

Elizabeth Brown

Principal Investigator

Statistical Data and Management Center

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Credit: FHCRC

 

Connie Celum

Principal Investigator

Leadership and Operations Center

University of Washington Support Core

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Credit: University of Washington

 

Charlene Dezzutti        

Principal Investigator

Laboratory Center

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Sharon Hillier

MTN Principal Investigator

Leadership and Operations Center

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Kristine Torjesen

Principal Investigator

Leadership and Operations Center

FHI 360 Support Core

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Graphics and Illustrations

 

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HIV infects T cells, one of several immune system cells, which have a specific molecule on its surface called a CD4 receptor. The receptor serves as a docking station where HIV sits before invading the cell. T cells are not found on the surface of the vagina, but below the epithelium, these and other target cells are found in abundance. How HIV reaches these cells is not certain. Perhaps HIV hitches a ride with dendritic cells that straddle the two layers, having conveniently been captured by these cells as an “invader” to be turned over to T cells and other immune cells that would otherwise orchestrate an attack. Or maybe the virus uses more direct routes through breaks in the tissue caused by local trauma and/or a sexually transmitted infection.