Microbicide Trials Network

Studies

Protocol Number Protocol ID Protocol Title
Closed to Accrual
MTN-020 11840 A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Phase 3 Safety and Effectiveness Trial of a Vaginal Matrix Ring Containing Dapivirine for the Prevention of HIV-1 Infection in Women
Closed to Follow Up
MTN-003D 11893 An Exploratory Study of Potential Sources of Efficacy Dilution in the VOICE Trial
MTN-008 10805 Expanded Safety of Tenofovir 1% Gel in Pregnancy and Lactation
MTN-011 11825 Phase 1 Evaluation of Coitus on the Pharmacokinetics and Pharmacodynamics of Tenofovir 1% Gel Following Pericoital or Daily Gel Dosing
Concluded
HPTN 035 10065 Phase II/IIb Safety and Effectiveness Study of the Vaginal Microbicides BufferGel and 0.5% PRO2000/5 Gel (P) for the Prevention of HIV Infection in Women
HPTN 059 10145 Phase II Expanded Safety and Acceptability Study of the Vaginal Microbicide 1% Tenofovir Gel
Enrolling
MTN-014 11885 A Phase 1 Crossover Trial Evaluating the Pharmacokinetics of Tenofovir Reduced-Glycerin 1% Gel in the Rectal and Vaginal Compartments In Women
MTN-015 10529 An Observational Cohort Study of Women following HIV-1 Seroconversion in Microbicide Trials
MTN-016 10737 HIV Prevention Agent Pregnancy Exposure Registry
MTN-017 11857 A Phase 2 Randomized Sequence Open Label Expanded Safety and Acceptability Study of Oral Emtricitabine/Tenofovir Disoproxil Fumarate Tablet and Rectally-Applied Tenofovir Reduced-Glycerin 1% Gel.
MTN-023/IPM 030 11927 Phase 2a Safety Study of a Vaginal Ring Containing Dapivirine in Adolescent Females
MTN-024/IPM 031 11915 Phase 2a Safety and Acceptability Study of a Vaginal Matrix Ring Containing Dapivirine in a Post-Menopausal Female Population
Participants off Study and Primary Analysis Completed
MTN-001 10617 Phase 2 Adherence and Pharmacokinetics Study of Oral and Vaginal Preparations of Tenofovir
MTN-002 10600 Phase I Study of the Maternal Single-Dose Pharmacokinetics and Placental Transfer of Tenofovir 1% Vaginal Gel among Healthy Term Gravidas
MTN-003 10622 Phase 2B Safety and Effectiveness Study of Tenofovir 1% Gel, Tenofovir Disoproxil Fumarate Tablet and Emtricitabine/Tenofovir Disoproxil Fumarate Tablet for the Prevention of HIV Infection in Women
MTN-003-P01 11835 The Wisebag Observational Pilot Study: Feasibility, Acceptability and Performance of an Electronic Event-based Monitoring System (Wisebag)
MTN-003B 10709 Bone Mineral Density Substudy
MTN-003C 10746 Household and Community Level Factors Associated with Study Product Adherence in VOICE: A Substudy of MTN-003
MTN-004 10492 Phase 1 Study of the Safety and Acceptability of 3% w/w SPL7013 Gel (VivaGelĀ®) Applied Vaginally in Sexually Active Young Women
MTN-005 10635 Expanded Safety and Acceptability Study of a Non-medicated Intravaginal Ring
MTN-007 10736 A Phase 1 Randomized, Double-Blinded, Placebo-Controlled Rectal Safety and Acceptability Study of Tenofovir 1% Gel
MTN-009 10791 Prevalence of HIV-1 Drug Resistance within a Female Screening Population for HIV Prevention Trials
MTN-012/IPM 010 11771 Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures
MTN-013/IPM 026 11772 Phase 1 Safety and Pharmacokinetics of Dapivirine/Maraviroc Intravaginal Ring
RMP-02/MTN-006 10769 Phase 1 rectal microbicide safety and acceptability trial of topically applied tenofovir compared with oral tablet
Pending
MTN-019 11839 Phase 2 Expanded Safety Study of Tenofovir Gel in Pregnancy
MTN-021 11843 Phase 1 Safety and Acceptability Study of 1% Tenofovir Gel in Adolescent Females
Withdrawn
HVTN 095/MTN-022 11852 Phase 1 Safety and Immunogenicity of DNA/NYVAC Prime Boost Vaccination With/Without Emtricitabine/Tenofovir
MTN-003C-01 11860 PREMIS: Preventive Misconception in HIV Prevention Trials
MTN-010 11682 Phase 2 Expanded Safety Study of UC781 0.25% Gel Used Daily Among Sexually Active Women
MTN-018 11818 Post-Trial Follow-up Safety Study to MTN-003
MTN-018B 11846 Committed to Having Options for Interventions to Control the Epidemic: A Follow-up Study to MTN-003 - Breastfeeding Sub-study
MTN-018C 11847 Committed to Having Options for Interventions to Control the Epidemic: A Follow-up Study to MTN-003 - Pregnancy Sub-study