Back to top

The following images are available for download. Unless otherwise noted, please credit Microbicide Trials Network, University of Pittsburgh and Magee-Womens Research Institute. If you have questions about these images or would like additional caption information, please contact Lisa Rossi at rossil@upmc.edu.

 

Microbicides

 

Different Formulations of Microbicides Image

 

 

 

 

 

different

formulations

Download high resolution jpeg

 

Microbicide Ring Image

 

 

 

 

 

vaginal ring

Download high resolution jpeg

Scientists Holding Ring in Hand Image

 

vaginal ring

Download high resolution jpeg

placebo insert 

 

 

 

placebo insert

Download high resolution jpeg

placebo douche image

 

 

 

 

 

placebo douche

Download high resolution jpeg

Placebo Suppository Image

 

 

 

placebo suppository

Download high resolution jpeg

Scientist Holding Microbicide Film Image

 

microbicide film

Download high resolution jpeg

Microbicide Film Image

 

microbicide film

Download high resolution jpeg

Study Gel and Applicator Image

 

study gel and

applicator

Download high resolution jpeg

 

 

 

Microbicides can be formulated in different ways.

 

Research

 

Research 1 Image

 

 

 

Research 1

Download high resolution jpeg

Research 2 Image

 

 

 

Research 2

Download high resolution jpeg

 

Using a unique tissue explant model that very closely mimics how HIV infects cells of the cervix or rectum, MTN researchers are able to test different products for their safety and effectiveness.

 

Research 3 Image

 

 

 

Research 3

Download high resolution jpeg

Research 4 Image

 

 

 

Research 4

Download high resolution jpeg

Research 5 Image

 

 

 

Research 5

Download high resolution jpeg

                       

MTN researchers perform studies that assess the stability of drug compounds in different formulations of microbicides.

 

Research 6 Image

 

 

 

Research 6

Download high resolution jpeg

 

MTN researchers look closely for any effects that microbicides may have on the normal population of vaginal microflora, studies that are important for assessing the safety of different products.

 

People

 

Sharon Hillier Image

 

 

 

 

Sharon Hillier
MTN Principal Investigator
Leadership and Operations Center
University of Pittsburgh
Download high resolution jpeg

Elizabeth Brown Image

 

 

 

 

 

 

Elizabeth Brown

Principal Investigator

Statistical Data & Management Center

Download high resolution jpeg

Credit: FHCRC

Connie Celum Image

 

 

 


 

Connie Celum

Principal Investigator

Leadership and Operations Center

UW Support Core

Download high resolution jpeg

Credit: University of Washington

 

Kristine Torjesen Image

 

 

 

 

 

Kristine Torjesen

Principal Investigator

Leadership and Operations Center

FHI 360 Support Core

Download high resolution jpeg

 

John Mellors Image

 

 

 


 

John Mellors

Principal Investigator

Laboratory Center

University of Pittsburgh

Download high resolution jpeg

Lisa Rohan Image

 

 

 


 

Lisa Rohan

Principal Investigator

Laboratory Center

University of Pittsburgh

Download high resolution jpeg

 

 

Graphics and Illustrations

 

How HIV Infects Vaginal Tissue Image

 

 

 

 

Download high resolution jpeg

 

HIV infects T cells, one of several immune system cells, which have a specific molecule on its surface called a CD4 receptor. The receptor serves as a docking station where HIV sits before invading the cell. T cells are not found on the surface of the vagina, but below the epithelium, these and other target cells are found in abundance. How HIV reaches these cells is not certain. Perhaps HIV hitches a ride with dendritic cells that straddle the two layers, having conveniently been captured by these cells as an “invader” to be turned over to T cells and other immune cells that would otherwise orchestrate an attack. Or maybe the virus uses more direct routes through breaks in the tissue caused by local trauma and/or a sexually transmitted infection.